February 9, 2018

When describing the clinical experience of  treating a person who has multiple chronic illnesses, negative synergy, where the whole is greater than the sum of its parts, is what comes to mind. Such patients almost always have these additional symptoms, usually around the their level of vitality that cannot be explained away by any one of their underlying, well-defined conditions yet are often quite functionally impairing.  Moreover, these are the symptoms that patients with multiple chronic illnesses rarely if ever mention nor are they inquired about, in any critical way, by their healthcare providers. These are precisely the symptoms that me, Corey and our patients with multiple chronic illnesses find the most gratifying to recognize and treat aggressively.



January 29, 2017

Your mission is to create a High-Performance Organization.

You have invested significant capital and resource in attracting and retaining talent; the key asset in your organization’s portfolio.

You are committed to providing a workplace culture of continuous growth so you diligently measure the performance of your enterprise, your executives and your employees. You reward your stars and you find those employees who are lagging and need further attention.

You have all the personal attributes and tools of a high performance leader, which is rare and valuable in today’s highly competitive business environment.

However, in spite of these achievements some of your executives performance is lagging behind their true potential. You give them coaching and performance improvement plans. Yet, you are frustrated over the negative impact on your bottom-line from lost productivity and in the worst case scenario the financial and human toll from the loss and replacement of talent.

I am certain that I can help you.

I am a Board Certified Internist and a Clinical Psychopharmacologist with nearly 30 years of clinical experience in helping people optimize their health, wellbeing and performance.

I do much more than simply coach executives and employees.

Einstein said if he had just one hour to save the world he would spend fifty-five minutes defining the problem and five minutes finding the solution. As a seasoned clinical neuroscientist I am able connect an executive’s performance to its structural underpinnings, thus defining his or her performance problem, from which I derive a solution. This is the tool in my skill-set that separates me from  all other executive coaches.

I don’t expect you to take my word for it, so please see what my clients have to say about my clinical services.

I offer my executive coaching services with strict adherence to HIPAA. I am confident that the performance outcomes of my executive coaching will speak for itself.

If I can be of service to you and your high performance organization, it would be my pleasure and privilege to serve.


Mitchell R. Weisberg, MD, MP

The Executive Whisperer at Optimal Performance, MD


Phone: (847) 999-5120

Book Appointment with Optimal Performance MD in Skokie, Illinois

Source: Book Appointment with Optimal Performance MD

Mitchell R Weisberg MD is a Board Certified Internist and Clinical Psychopharmacologist in private medical practice in the Chicago area since 1990. Within his practice, Dr. Weisberg developed and honed a holistic clinical method he calls, Optimal Performance MD, by which he helps his patients optimize their health, well-being and performance.

In August 2017, Dr. Weisberg became the Chief Medical Officer at ViMedicus; a Chicago based Healthcare Services/ Technology startup. ViMedicus services self-insured Organizations creating solutions that combine healthcare intelligence, care coordination, and collaborative communications to empower service providers and help improve the lives of individuals with chronic conditions.

Dr. Weisberg did his Medical School and Internal Medicine training at Rush University in Chicago, where in 1991 he served as Chief Medical Resident in the Department of Internal Medicine. In 2006, Dr. Weisberg received his certification as a Master Psychopharmacologist (MP) from The Neuroscience Education Institute, Carlsbad, CA.  His unique credentials allowed Dr. Weisberg to serve as a Primary Care Neuroscience Consultant and Educator for Eli Lilly and Company, educating his primary care colleagues on the recognition and treatment of Depression, Bipolar Disorder and Adult Attention Deficit Hyperactivity Disorder in the primary care setting. In addition, Dr. Weisberg has maintained his Board Certification by the American Board of Internal Medicine since 1990 passing his re-certification examination in October 2014.Dr. Weisberg’s proudest achievement is each of the individuals he helped.

A person IS what a person DOES

Our performance, that is all that we do, how well or how poorly we do it is the furthest downstream effect and thus the ultimate manifestation of our subjective sense well-being.

Proof of the link between Neuroplasticity and Performance

If asked to describe the most fundamental of all scientific principles my answer is the inherent relationship between a physical object’s structure and function. Whether an element on the periodic table, a suspension bridge or a distant galaxy; and regardless of its scale, from subatomic to astronomical, inherent within every physical object in the known universe is this immutable link between its structure and functionUs human beings, arguably one of the most complex objects in the known universe, are no exception to this principle.

Human performance is defined as accomplishing tasks according to agreed upon standards of accuracy, completeness, and efficiency. Therefore, human performance is the willful and measurable part of a human-being’s function which begs the question, what is the underlying structure of human performance?

The first layer we see if we peel back our performance is a collective of individual behaviors, each of which is executed exclusively and entirely by the moveable human body; its skeleton, muscles and connective tissues. Pull back just one more layer to expose that each of these component behaviors is the immediate reflection of the core of our performance; the neuroplastic molecular structure of our Central Nervous System (CNS).

While macroscopically it appears as a solid structure, at the microscopic level the human brain is plastic, even liquid or soup-like whose molecular ingredients continuously and instantaneously change via the inter-neuron electrical-chemical communication process known as neurotransmission, which in its collective form is commonly called neuroplasticity. While it begins with neurotransmission, neuroplasticity ultimately leads to structural changes in the circuits and other structural elements of our brains. And this process occurs throughout our entire lives, not just through childhood and adolescent neuro-development as once thought.

To illustrate neuroplasticity, consider a soldier on the battlefield who suffers a shrapnel injury to his shoulder. The first thing the battle-field medic does when she comes upon the wounded soldier is inject him as much morphine as it takes to ease the soldier’s pain so he can lie still, allowing her to safely examine and treat his wound. If the soldier was given this exact dosage of morphine one millisecond before he suffered the shrapnel wound he would have died instantly due to respiratory suppression effect of morphine. However, simultaneously with the shrapnel penetrating the soldier’s flesh the molecular ingredients, in the receptors on the surface of the soldier’s neurons (brain cells) structurally changed in a way which allowed morphine to act as an analgesic (pain reliever) rather than a respiratory suppressant. This is neuroplasticity in action, and it happens faster than you can add a dash of salt to bland soup.

A mortal wound is not required to set neuroplasticity into motion. In fact, neuroplasticity is occurring continuously from the embryonic stage throughout the lifetime of every human-being. As in the wounded soldier, the effects of neuroplasticity can be instantaneous. Neuroplasticity also occurs more slowly over time such as a soldier who develops PTSD or when we learn new motor skills such as playing golf or the piano. Neuroplasticity can be maladaptive (pathologic) or adaptive as these examples show. Neuroplasticity is a variable process within every human being that occurs spontaneously as well as in response to a stimuli, whether internal (within the person, such as an infection other disease process) or external (in the person’s environment). Neuroplasticity is a highly evolved process, while at the same time is the primary process that has continuously driven human evolution forward. Neuroplasticity is the chisel from which the human brain, the one organ that definitively distinguishes humans from every other species on the planet, has been meticulously sculpted over millions of years. Neuroplasticity is what allowed our prehistoric ancestors to successfully adapt to an ever-changing, ever-challenging environment we commonly refer to as Planet Earth, through a process, which in evolutionary terms has come to be known as natural selection. For millions of years neuroplasticity has played, and continues to play, the leading role in the continuing saga, first documented by Darwin and referred to ever since as the evolution of our species. Neuroplasticity is the process that can singularly be credited with making humans fit to survive and fit to strive.

The impact of neuroplasticity on human performance is ubiquitous. The effects on our health and performance from regular exercise, good nutrition and sleep as well as the impact the of drugs, both prescribed and illicit, favorable and unfavorable, are all mediated via this single process called neuroplasticity.  So, when we peel back the layers of human performance (function), at its core we find a soup whose molecular ingredients are constantly changing based on the stimuli to which we are exposed. To the same extent that an internal stimulus, such as a disease or a drug, or an external stimulus, such as a traumatic event or winning the lottery, affects the ingredients within this bowl of soup, is the same extent to which it affects our performance.

The link between our subjective sense of Wellbeing and Neuroplasticity

To begin this section, I want every reader to rate their subjective sense of wellbeing (physical, mental, spiritual) over the past week on a scale of 1 (horrible) thru 10 (outstanding).  Our subjective sense of wellbeing sets the upper limits on our performance in all spheres of our life; interpersonal (social), academic and vocational. In short, we cannot perform better than we feel. When we describe our wellbeing as a 5 on a 10 scale, we cannot possibly perform better than a 5. We are a 5 or lower as a spouse, a parent, a friend, at school or at whatever it is we do for a living.

Why is this? 

When we describe our subjective sense of wellbeing, we are describing the current structure of our ever-changing neuroplastic state; and for every structure exists functional limitations. For example, if an engineer designed a bridge to bear a load of 20 tons, put 21 tons on this bridge and it fails. In its broadest terms, the author’s hypothesis states that the underlying structure of a human being’s current performance is his or her current neuroplastic state. Therefore, whatever your rating of your subjective sense of wellbeing is, it represents the current state of your continuously changing neuroplasticity. So, if your answer was a 9 or a 10 take note, benchmark I’m begging you, all of your life-habits are and keep them up. If your answer is 5 or lower, I don’t want to alarm you and I am certain you are already aware of this but your low-level of wellbeing is manifest in your current performance in all spheres of your life. In my professional opinion you need and deserve attention, the entire focus of which is your current state of wellbeing, the internal and environmental contributors to this state and all of their potential remedies. No less than this is required in order to optimize human performance


Our performance is our ultimate vital sign as it is a direct reflection of our neuroplastic state. Our subjective sense of wellbeing is a further reflection of our neuroplastic state. Since structure and function are immutably linked, we can only perform as well as we feel. Therefore, we need to pay attention to how we feel. When we don’t feel well, it is incumbent upon us to figure out, as best we can, the reasons for it and pursue potential remedies. Who we are depends on this.


End Post

Mitchell R. Weisberg, MD, MP

Internist-Psychopharmacologist-Corporate Wellness Consultant

Founder-CEO and Personal Physician at:

Optimal Performance MD


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